Spangler D L, Vanderpool G E, Carroll M S, Tinkelman D G
Ann Allergy. 1980 Dec;45(6):355-9.
Bioavailability and theophylline level variability were compared between a standard theophylline elixir and a new sustained release theophylline tablet. The results demonstrate a good bioavailability and a reduced dosage interval with less theophylline level variability for the sustained release tablet, administered every 12 hours, than with the immediate release product, every six hours.
对标准氨茶碱酏剂和新型氨茶碱缓释片的生物利用度及茶碱水平变异性进行了比较。结果表明，与每6小时服用一次的速释产品相比，每12小时服用一次的缓释片具有良好的生物利用度，且给药间隔时间延长，茶碱水平变异性降低。
