Thurston J R, Baetz A L, Cheville N F, Richard J L
Am J Vet Res. 1980 Aug;41(8):1272-6.
Guinea pigs were fed a single toxic but sublethal dose of aflatoxin. Serum proteins, complement activity, fourth component of complement (C4), and liver enzymes (ornithine carbamoyltransferase and sorbitol dehydrogenase) as well as microscopic changes in liver tissue, were studied to correlate structural and functional abnormalities. There were no significant changes in serum proteins, but complement activity and C4 were depressed maximally 7 days after aflatoxin was given. The greatest activity of the liver enzymes in plasmas occurred at 3 days, although sorbitol dehydrogenase activity still was elevated significantly on the 7th day. Microscopic changes in the liver were maximum at 3 days with gradual recovery at 7, 10, and through 14 days.
给豚鼠喂食单一毒性但亚致死剂量的黄曲霉毒素。研究了血清蛋白、补体活性、补体第四成分（C4）、肝酶（鸟氨酸氨甲酰转移酶和山梨醇脱氢酶）以及肝组织的微观变化，以关联结构和功能异常。血清蛋白无显著变化，但补体活性和C4在给予黄曲霉毒素后7天降至最低。血浆中肝酶的最大活性出现在3天，尽管山梨醇脱氢酶活性在第7天仍显著升高。肝脏的微观变化在3天达到最大，在7天、10天以及直至14天逐渐恢复。
