Richard J L, Thurston J R, Lillehoj E B, Cysewski S J, Booth G D
Am J Vet Res. 1978 Jan;39(1):163-6.
Effects of either sterigmatocystin or aflatoxin, alone or in combination, given orally to guinea pigs were studied. Sterigmatocystin and aflatoxin B1 given alone and in combination at 4.2 mg/day and 0.01 mg/day, respectively, markedly reduced body weight. Although changes in total serum protein were not marked in any of the guinea pigs in this study, sterigmatocystin given alone and aflatoxin given alone significantly ( less than 0.05) decreased alpha2-globulin. The combination of toxins significantly (P less than 0.01) increased albumin and significantly (P less than 0.01) decreased both alpha2- and beta-globulins. Sterigmatocystin depressed complement activity, although not significantly. However, the combination of sterimatocystin with 0.01 mg of aflatoxin B1/day (an amount that does not affect complement activity alone) significantly (P less than 0.01) reduced complement activity. Increased severity of lesions was not found in guinea pigs given aflatoxin at 0.01 mg of B1 equivalents/day in addition to the sterigmatocystin.
研究了单独或联合口服柄曲霉素或黄曲霉毒素对豚鼠的影响。单独给予柄曲霉素和黄曲霉毒素B1，以及联合给予时，剂量分别为每天4.2毫克和0.01毫克，均显著降低了体重。尽管在本研究中任何豚鼠的总血清蛋白变化均不明显，但单独给予柄曲霉素和单独给予黄曲霉毒素均显著（P<0.05）降低了α2球蛋白。毒素联合使用显著（P<0.01）增加了白蛋白，并显著（P<0.01）降低了α2球蛋白和β球蛋白。柄曲霉素降低了补体活性，尽管不显著。然而，柄曲霉素与每天0.01毫克黄曲霉毒素B1联合使用（该剂量单独使用时不影响补体活性）显著（P<0.01）降低了补体活性。除柄曲霉素外，每天给予0.01毫克B1当量黄曲霉毒素的豚鼠未发现病变严重程度增加。
