广谱头孢菌素Ro 13-9904的药代动力学
Pharmacokinetics of Ro 13-9904, a broad-spectrum cephalosporin.
作者信息
Seddon M, Wise R, Gillett A P, Livingston R
出版信息
Antimicrob Agents Chemother. 1980 Aug;18(2):240-2. doi: 10.1128/AAC.18.2.240.
Abstract
The pharmacokinetics of the new cephalosporin Ro-13-9904 were studied in six healthy male volunteers receiving a 500-mg dose as a bolus intravenously. Tissue penetration of the antibiotic was estimated by using a cantharides blister method. The data obtained fitted a two-compartment open model. The mean elimination half-life was about 8 h, which is considerably longer than that of other beta-lactam compounds. The distribution volume was 4.3 liters in the central compartment. Levels of Ro 13-9904 in blister fluid exceeded those in serum after 6.5 h. Approximately 60% of the antibiotic was excreted in the urine.
摘要
在6名健康男性志愿者中进行了新型头孢菌素Ro-13-9904的药代动力学研究，他们静脉推注了500毫克剂量的该药物。采用斑蝥水疱法评估抗生素的组织穿透性。所获得的数据符合二室开放模型。平均消除半衰期约为8小时，这比其他β-内酰胺类化合物的半衰期长得多。中央室的分布容积为4.3升。6.5小时后，水疱液中Ro 13-9904的水平超过了血清中的水平。约60%的抗生素经尿液排泄。
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