Wise R, Cadge B, Gillett A P, Bhamjee A, Livingston R, Welling P G, Thornhill D P
Antimicrob Agents Chemother. 1979 May;15(5):670-3. doi: 10.1128/AAC.15.5.670.
The pharmacokinetics of the broad-spectrum penicillin Bay k 4999 were studied in six healthy male volunteers. A 2-g dose was given by the intravenous route. The tissue penetration of the antibiotic was studied by both dermabrasion and blister techniques. A total of 26.4% of the drug was recovered in the urine in 24 h, 79% of this being excreted in the first 2 h. The elimination half-life in serum was 1.3 h. The dermabrasion levels of Bay k 4999 were generally similar to those in serum, but after 1 h the blister fluid levels of antibiotic were greater than those in serum. Different drug levels obtained by blister and dermabrasion techniques may be due to the different composition of the two fluids.
在六名健康男性志愿者中研究了广谱青霉素Bay k 4999的药代动力学。通过静脉途径给予2克剂量。采用磨皮和水疱技术研究了该抗生素的组织穿透情况。24小时内尿液中总共回收了26.4%的药物，其中79%在最初2小时内排出。血清中的消除半衰期为1.3小时。Bay k 4999的磨皮水平通常与血清中的水平相似，但1小时后水疱液中的抗生素水平高于血清中的水平。通过水疱和磨皮技术获得的不同药物水平可能是由于这两种液体的成分不同。
