氟氯西林和氯唑西林肠胃外给药所致静脉炎：一项双盲研究。

Phlebitis induced by parenteral treatment with flucloxacillin and cloxacillin: a double-blind study.

作者信息

Svedhem A, Alestig K, Jertborn M

出版信息

Antimicrob Agents Chemother. 1980 Aug;18(2):349-52. doi: 10.1128/AAC.18.2.349.

DOI:10.1128/AAC.18.2.349

PMID:7447412

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283994/

Abstract

Two studies were performed on a total of 54 patients with staphylococcal infections. Study I compares with phlebitogenic properties of flucloxacillin after intravenous infusions when either saline or sterile water was used as a solvent. No difference was observed between the two solvents, and the frequency of phlebitis for the total material without respect to solvents was 5% after 1 day of treatment and 13% after 2 days. Study II was a double-blind comparison of phlebitis caused by intravenous infusions of either flucloxacillin or cloxacillin. The frequencies of phlebitis were found to be 18 and 13%, respectively. After 2 days of treatment the frequency of phlebitis increased dramatically for both drugs. All infusions were given through a plastic cannula of 5-cm length and 1.2-mm diameter.

摘要

对总共54例葡萄球菌感染患者进行了两项研究。研究I比较了以生理盐水或无菌水作为溶剂静脉输注氟氯西林后的致静脉炎特性。两种溶剂之间未观察到差异，无论使用何种溶剂，整个研究对象中静脉炎的发生率在治疗1天后为5%，2天后为13%。研究II是一项关于静脉输注氟氯西林或氯唑西林所致静脉炎的双盲比较。发现静脉炎的发生率分别为18%和13%。治疗2天后，两种药物的静脉炎发生率均急剧上升。所有输注均通过一根长度为5厘米、直径为1.2毫米的塑料套管进行。