头孢乙腈、头孢唑林、甲氧西林和萘夫西林用于兔金黄色葡萄球菌性心内膜炎治疗的比较
Comparison of ceforanide, cefazolin, methicillin, and nafcillin in Staphylococcus aureus endocarditis therapy in rabbits.
作者信息
Carrizosa J, Kobasa W D, Kaye D
出版信息
Antimicrob Agents Chemother. 1980 Oct;18(4):562-5. doi: 10.1128/AAC.18.4.562.
Abstract
Ceforanide (30 mg/kg) administered every 12 h, cefazolin (20 mg/kg) administered every 8 h and methicillin or nafcillin (40 mg/kg) administered every 6 h were equally effective in reducing the number of Staphylococcus aureus in vegetations in rabbits with endocarditis. These treatments were more effective than methicillin or nafcillin administered every 12 h. Ceforanide produced higher peak concentrations and greater bactericidal activity in serum than the other drugs and had the longest half-life (5.8 h, compared with 0.4 to 0.8 h for the other agents.
摘要
每12小时给予头孢雷特（30毫克/千克）、每8小时给予头孢唑林（20毫克/千克）以及每6小时给予甲氧西林或萘夫西林（40毫克/千克），在减少患有心内膜炎的兔子赘生物中金黄色葡萄球菌数量方面效果相同。这些治疗方法比每12小时给予甲氧西林或萘夫西林更有效。头孢雷特在血清中产生的峰值浓度更高，杀菌活性更强，且半衰期最长（5.8小时，而其他药物为0.4至0.8小时）。
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2
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3
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