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1
Comparison of ceforanide, cefazolin, methicillin, and nafcillin in Staphylococcus aureus endocarditis therapy in rabbits.头孢乙腈、头孢唑林、甲氧西林和萘夫西林用于兔金黄色葡萄球菌性心内膜炎治疗的比较
Antimicrob Agents Chemother. 1980 Oct;18(4):562-5. doi: 10.1128/AAC.18.4.562.
2
Treatment of experimental Staphylococcus aureus endocarditis: comparison of cephalothin, cefazolin, and methicillin.实验性金黄色葡萄球菌心内膜炎的治疗：头孢噻吩、头孢唑林和甲氧西林的比较。
Antimicrob Agents Chemother. 1978 Jan;13(1):74-7. doi: 10.1128/AAC.13.1.74.
3
Effectiveness of nafcillin, methicillin, and cephalothin in experimental Staphylococcus aureus endocarditis.萘夫西林、甲氧西林和头孢噻吩在实验性金黄色葡萄球菌心内膜炎中的有效性。
Antimicrob Agents Chemother. 1979 May;15(5):735-7. doi: 10.1128/AAC.15.5.735.
4
Comparison of methicillin, nafcillin, and oxacillin in therapy of Staphylococcus aureus endocarditis in rabbits.甲氧西林、萘夫西林和苯唑西林治疗兔金黄色葡萄球菌性心内膜炎的比较。
J Lab Clin Med. 1977 Jun;89(6):1262-8.
5
Cefoperazone treatment of experimental endocarditis.头孢哌酮治疗实验性心内膜炎
Antimicrob Agents Chemother. 1981 May;19(5):773-6. doi: 10.1128/AAC.19.5.773.
6
Laboratory tests for defining bactericidal activity as predictors of antibiotic efficacy in the treatment of endocarditis due to Staphylococcus aureus in rabbits.用于确定杀菌活性作为兔金黄色葡萄球菌性心内膜炎治疗中抗生素疗效预测指标的实验室检测。
J Infect Dis. 1984 Jun;149(6):904-12. doi: 10.1093/infdis/149.6.904.
7
Teicoplanin versus nafcillin and vancomycin in the treatment of experimental endocarditis caused by methicillin-susceptible or -resistant Staphylococcus aureus.替考拉宁与萘夫西林及万古霉素治疗由甲氧西林敏感或耐药金黄色葡萄球菌引起的实验性心内膜炎的比较。
Antimicrob Agents Chemother. 1984 Jul;26(1):61-4. doi: 10.1128/AAC.26.1.61.
8
A comparison of safety and outcomes with cefazolin versus nafcillin for methicillin-susceptible Staphylococcus aureus bloodstream infections.头孢唑林与萘夫西林治疗甲氧西林敏感金黄色葡萄球菌血流感染的安全性和结局比较。
J Microbiol Immunol Infect. 2020 Apr;53(2):321-327. doi: 10.1016/j.jmii.2018.07.006. Epub 2018 Aug 18.
9
Antimicrobial prophylaxis of experimental endocarditis caused by Staphylococcus epidermidis.表皮葡萄球菌所致实验性心内膜炎的抗菌预防
Infection. 1989 Mar-Apr;17(2):90-6. doi: 10.1007/BF01646884.
10
Methicillin-Susceptible Staphylococcus Aureus Bacteremia: Cefazolin in Prime But Nafcillin Not Ready for an Exit.
Am J Med Sci. 2020 Jul;360(1):3-4. doi: 10.1016/j.amjms.2020.04.007. Epub 2020 Apr 15.

引用本文的文献

1
Teicoplanin versus nafcillin and vancomycin in the treatment of experimental endocarditis caused by methicillin-susceptible or -resistant Staphylococcus aureus.替考拉宁与萘夫西林及万古霉素治疗由甲氧西林敏感或耐药金黄色葡萄球菌引起的实验性心内膜炎的比较。
Antimicrob Agents Chemother. 1984 Jul;26(1):61-4. doi: 10.1128/AAC.26.1.61.
2
Ceforanide. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy.头孢雷特。对其抗菌活性、药代动力学特性及临床疗效的综述。
Drugs. 1987 Oct;34(4):411-37. doi: 10.2165/00003495-198734040-00001.

本文引用的文献

1
IN VITRO AND IN VIVO LABORATORY EVALUATION OF CEPHALOGLYCIN AND CEPHALORIDINE.头孢甘氨酸和头孢噻啶的体外及体内实验室评估
Appl Microbiol. 1965 Mar;13(2):248-53. doi: 10.1128/am.13.2.248-253.1965.
2
Pharmacology of cefazolin in patients with normal and abnormal renal function.
J Infect Dis. 1973 Oct;128:Suppl:S354-7. doi: 10.1093/infdis/128.supplement_2.s354.
3
Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens.实验性链球菌性心内膜炎的化疗。I. 常用推荐预防方案的比较。
J Clin Invest. 1973 Mar;52(3):592-8. doi: 10.1172/JCI107220.
4
Comparison of methicillin, nafcillin, and oxacillin in therapy of Staphylococcus aureus endocarditis in rabbits.甲氧西林、萘夫西林和苯唑西林治疗兔金黄色葡萄球菌性心内膜炎的比较。
J Lab Clin Med. 1977 Jun;89(6):1262-8.
5
Antibiotic synergism in enterococcal endocarditis.肠球菌性心内膜炎中的抗生素协同作用。
J Lab Clin Med. 1976 Jul;88(1):132-41.
6
Treatment of experimental Staphylococcus aureus endocarditis: comparison of cephalothin, cefazolin, and methicillin.实验性金黄色葡萄球菌心内膜炎的治疗：头孢噻吩、头孢唑林和甲氧西林的比较。
Antimicrob Agents Chemother. 1978 Jan;13(1):74-7. doi: 10.1128/AAC.13.1.74.
7
Clinical pharmacokinetics and safety of high doses of ceforanide (BL-S786R) and cefazolin.高剂量头孢雷特（BL-S786R）和头孢唑林的临床药代动力学及安全性
Antimicrob Agents Chemother. 1979 Nov;16(5):615-21. doi: 10.1128/AAC.16.5.615.
8
Ceforanide: in vitro and clinical evaluation.头孢雷特：体外及临床评估
Antimicrob Agents Chemother. 1979 Sep;16(3):386-91. doi: 10.1128/AAC.16.3.386.

头孢乙腈、头孢唑林、甲氧西林和萘夫西林用于兔金黄色葡萄球菌性心内膜炎治疗的比较

Comparison of ceforanide, cefazolin, methicillin, and nafcillin in Staphylococcus aureus endocarditis therapy in rabbits.

作者信息

Carrizosa J, Kobasa W D, Kaye D

出版信息

Antimicrob Agents Chemother. 1980 Oct;18(4):562-5. doi: 10.1128/AAC.18.4.562.

DOI:10.1128/AAC.18.4.562
PMID:7447418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284049/
Abstract

Ceforanide (30 mg/kg) administered every 12 h, cefazolin (20 mg/kg) administered every 8 h and methicillin or nafcillin (40 mg/kg) administered every 6 h were equally effective in reducing the number of Staphylococcus aureus in vegetations in rabbits with endocarditis. These treatments were more effective than methicillin or nafcillin administered every 12 h. Ceforanide produced higher peak concentrations and greater bactericidal activity in serum than the other drugs and had the longest half-life (5.8 h, compared with 0.4 to 0.8 h for the other agents.

摘要

每12小时给予头孢雷特（30毫克/千克）、每8小时给予头孢唑林（20毫克/千克）以及每6小时给予甲氧西林或萘夫西林（40毫克/千克），在减少患有心内膜炎的兔子赘生物中金黄色葡萄球菌数量方面效果相同。这些治疗方法比每12小时给予甲氧西林或萘夫西林更有效。头孢雷特在血清中产生的峰值浓度更高，杀菌活性更强，且半衰期最长（5.8小时，而其他药物为0.4至0.8小时）。