Inoki R, Hayashi T, Matsumoto K, Kotani Y, Oka M
Arch Int Pharmacodyn Ther. 1980 Oct;247(2):283-93.
Effects of morphine on the release of a bradykinin-like substance into the subcutaneous perfusate of the rat paw, elicited by pinching and heating of the foot instep and by electrical stimulation of the sciatic nerve, were investigated. Morphine (5 mg/kg i.m.) inhibited the release of a bradykinin-like substance only when sciatic nerve stimulation was applied. The release due to sciatic nerve stimulation was not inhibited by gallamine (8 mg/kg i.p.), but significantly by physostigmine (1 mg/kg i.p.). The release was also observed by adrenergic agents and was inhibited by adrenergic alpha-blocking agents. No release of a bradykinin-like substance due to sciatic nerve stimulation was observed in reserpinized and 6-hydroxydopaminized rats. Dopa restored the releasing ability due to sciatic nerve stimulation in the reserpinized rats, but not in the 6-hydroxydopaminized ones. The results suggest that the inhibitory action of morphine can be explained by an inhibition of the release of noradrenaline.
研究了吗啡对通过捏夹和加热足背以及电刺激坐骨神经引起的大鼠爪皮下灌流液中类缓激肽物质释放的影响。吗啡（5毫克/千克，肌肉注射）仅在施加坐骨神经刺激时抑制类缓激肽物质的释放。由坐骨神经刺激引起的释放不受加拉明（8毫克/千克，腹腔注射）抑制，但受毒扁豆碱（1毫克/千克，腹腔注射）显著抑制。肾上腺素能药物也可观察到释放，且受肾上腺素能α受体阻断剂抑制。在利血平化和6-羟基多巴胺处理的大鼠中，未观察到因坐骨神经刺激而导致的类缓激肽物质释放。多巴可恢复利血平化大鼠因坐骨神经刺激的释放能力，但不能恢复6-羟基多巴胺处理大鼠的该能力。结果表明，吗啡的抑制作用可通过去甲肾上腺素释放的抑制来解释。
