Inoki R, Hayashi T, Kudo T, Matsumoto K, Oka M, Kotani Y
Arch Int Pharmacodyn Ther. 1977 Jul;228(1):126-35.
Coaxial perfusion was carried out in the rat paw; pinching the instep of the foot and electrical stimulation of the sciatic nerve caused an increase in the release of a bradykinin-like substance and kinin forming enzyme into the perfusate. Release of the latter was noted with pinching even independently of the release of the bradykinin-like substance. Acetylsalicylic acid (200 mg/kg i.p.) inhibited the release of kinin forming enzyme due to pinching or to sciatic nerve stimulation, while morphine (5 mg/kg i.m.) inhibited only the release of the enzyme due to sciatic nerve stimulation. Our results suggest that production of localized pain may be largely due to the activity of the released kinin forming enzyme and the bradykinin-like substance. In addition, the mechanism of inhibition by morphine on release of kinin forming enzyme appears to differ from that of acetylsalicylic acid.
在大鼠爪部进行同轴灌注；捏压脚背以及电刺激坐骨神经会导致灌流液中一种类缓激肽物质和激肽形成酶的释放增加。即使在不释放类缓激肽物质的情况下，捏压也会引起激肽形成酶的释放。乙酰水杨酸（200毫克/千克腹腔注射）抑制因捏压或坐骨神经刺激引起的激肽形成酶的释放，而吗啡（5毫克/千克肌肉注射）仅抑制因坐骨神经刺激引起的该酶的释放。我们的结果表明，局部疼痛的产生可能很大程度上归因于所释放的激肽形成酶和类缓激肽物质的活性。此外，吗啡对激肽形成酶释放的抑制机制似乎与乙酰水杨酸不同。
