Di Simplicio P, Palmi M, Ruggiero P, Segre G
Boll Soc Ital Biol Sper. 1980 Apr 30;56(8):795-801.
In rats treated with thioacetamide (250 mg/Kg i.p.) the glutathione-S-transferase activity in liver and in plasma and the glutathione content in liver have been determined at various times. The glutathione-S-transferase activity in liver supernatant decreases after 24 and 48 hours and returns to normal values after 4 days. The glutathione-S-transferase activity in liver supernatant is not inhibited by thioacetamide at 20 mM. The glutathione-S-transferase activity appears in plasma after 12 hours, with a maximum at 24 hours, followed to a decrease toward zero levels; this activity can be determined in plasma even at a dose of 10 mg/Kg of thioacetamide. The glutathione content in liver increases at 48 and 96 hours after drug administration.
在用硫代乙酰胺（250毫克/千克，腹腔注射）处理的大鼠中，在不同时间测定了肝脏和血浆中的谷胱甘肽-S-转移酶活性以及肝脏中的谷胱甘肽含量。肝脏上清液中的谷胱甘肽-S-转移酶活性在24小时和48小时后降低，并在4天后恢复到正常值。20毫摩尔的硫代乙酰胺不抑制肝脏上清液中的谷胱甘肽-S-转移酶活性。谷胱甘肽-S-转移酶活性在12小时后出现在血浆中，在24小时达到最大值，随后下降至零水平；即使硫代乙酰胺剂量为10毫克/千克，也能在血浆中检测到这种活性。给药后48小时和96小时，肝脏中的谷胱甘肽含量增加。
