Zorich P A, Tronko N D, Mikosha A S
Fiziol Zh (1994). 1994 Jan-Feb;40(1):86-90.
The chloditan (o.p-DDD, mitotane), which causes the destruction of the human and dog adrenal cortex, on the most essential system of xenobiotic metabolism: glutathione-S-transferase--glutathione has been studied. The effect of o,p-DDD on GSH level and activity of glutathione-S-transferase and glutathione reductase which maintain the level of reduced glutathione was analyzed in the adrenal and liver tissue of rats. This species is resistant to adrenocorticolytic action of o,p-DDD. It was shown that feeding of rats weighting 200-240 g with oil solution of o,p-DDD (75 mg daily) for 3 days causes the decrease in activity of glutathione-S-transferase and content of oxidazed glutathione in the adrenals with simultaneous increase of the content of reduced glutathione. The glutathione-S-transferase and glutathione reductase activity in the liver rises under the effect of o,p-DDD, the decrease of the GSH level being observed. The revealed changes may explain the species sensitivity of animals to o,p-DDD.
已对导致人和犬肾上腺皮质破坏的氯地孕酮（邻对滴滴滴，米托坦）在最重要的外源性物质代谢系统——谷胱甘肽-S-转移酶方面进行了研究。分析了邻对滴滴滴对大鼠肾上腺和肝脏组织中谷胱甘肽水平以及维持还原型谷胱甘肽水平的谷胱甘肽-S-转移酶和谷胱甘肽还原酶活性的影响。该物种对邻对滴滴滴的肾上腺皮质溶解作用具有抗性。结果表明，给体重200 - 240克的大鼠每日喂食邻对滴滴滴油溶液（75毫克），持续3天，会导致肾上腺中谷胱甘肽-S-转移酶活性和氧化型谷胱甘肽含量降低，同时还原型谷胱甘肽含量增加。在邻对滴滴滴的作用下，肝脏中的谷胱甘肽-S-转移酶和谷胱甘肽还原酶活性升高，同时观察到谷胱甘肽水平降低。所揭示的这些变化可能解释了动物对邻对滴滴滴的物种敏感性。
