阿司匹林所致胃黏膜糜烂发病机制的超微结构观察
Ultrastructural observations on the pathogenesis of aspirin-induced gastric erosions.
作者信息
Robins P G
出版信息
Br J Exp Pathol. 1980 Oct;61(5):497-504.
Abstract
It is shown by transmission electron-microscopy that the first structural change in rats, following a dose of aspirin, is to the basement membrane of the endothelial cell of the capillary and post-capillary venule. This leads to the breakdown of small blood vessels before any other cytolytic effect. This is a focal effect and it is proposed that the erosion develops as an ischaemic infarct.
摘要
透射电子显微镜显示，给大鼠服用一定剂量的阿司匹林后，其首个结构变化发生在毛细血管和毛细血管后微静脉内皮细胞的基底膜。这会导致小血管破裂，且早于任何其他细胞溶解效应。这是一种局灶性效应，有人提出这种侵蚀是作为缺血性梗死发展而来的。
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