一种源自人类白细胞的热原，在小鼠体内具有活性。
A pyrogen derived from human white cells which is active in mice.
作者信息
Gordon A H, Parker I D
出版信息
Br J Exp Pathol. 1980 Oct;61(5):534-9.
Abstract
An endogenous pyrogen smaller in molecular size than that previously obtained from human white cells has been found in supernatants of these cells after uptake of zymosan and incubation for 18 h. The new pyrogen after separation from other pyrogens which are produced at the same time has been found to produce fever in mice but not in rabbits. Because it is not formed if cycloheximide is present and is inactivated by leucine aminopeptidase, it is believed to be a peptide.
摘要
在这些细胞摄取酵母聚糖并孵育18小时后的上清液中，发现了一种分子大小比先前从人白细胞中获得的内源性热原更小的物质。从同时产生的其他热原中分离出来后，这种新的热原已被发现可使小鼠发热，但不能使兔子发热。由于如果存在放线菌酮则不会形成这种热原，并且它会被亮氨酸氨肽酶灭活，因此人们认为它是一种肽。
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