Gartner S, Henkind P
Br J Ophthalmol. 1981 Jan;65(1):23-8. doi: 10.1136/bjo.65.1.23.
In a light microscopic study of the macula of 104 human eyes obtained at necropsy of patients aged 3 to 96 we found: (1) Displacement of nuclei from the outer nuclear layer into the outer plexiform layer occurred in small numbers early in life and markedly increased after age 30. (2) Displacement of nuclei from the outer nuclear layer to the layer of rods and cones was rare in early life but increased considerably after age 40. (3) Displacement of nuclei is probably secondary to shrinkage of their attached fibres and is associated with aging. (4) Displaced nuclei apparently undergo changes in size, shape, and chromatin content and may go on to necrosis. (5) Twenty-four of the 104 eyes studied had an obvious reduction in the numbers of nuclei in the outer nuclear layer and their photoreceptors in the macular zone. All were in eyes from patients over age 40. No concomitant defect was found in the subjacent pigment epithelium, Bruch's membrane, or the choriocapillaris. The loss of nuclei of the outer nuclear layer appears to be a primary retinal disorder associated with aging.
在对104只年龄在3岁至96岁患者尸检时获取的人眼黄斑区进行的光学显微镜研究中，我们发现：（1）细胞核从外核层移位至外丛状层在生命早期少量出现，30岁后显著增加。（2）细胞核从外核层移位至视杆和视锥层在生命早期罕见，但40岁后大幅增加。（3）细胞核移位可能继发于其附着纤维的萎缩，并与衰老相关。（4）移位的细胞核明显在大小、形状和染色质含量上发生变化，并可能继而坏死。（5）在研究的104只眼中，有24只眼的黄斑区外核层及其光感受器中的细胞核数量明显减少。所有这些眼均来自40岁以上的患者。在下方的色素上皮、布鲁赫膜或脉络膜毛细血管中未发现伴随缺陷。外核层细胞核的丢失似乎是一种与衰老相关的原发性视网膜疾病。
