Linhart-Colas N, Meignan M, Bok B, Rotman N, Gougerot M
Biomedicine. 1980 Oct;32(3):133-9.
A new labelling method of blood white cells using "cold" pyrophosphate and 99m-technetium pertechnetate was assessed in 6 normal dogs and 6 dogs with turpentine induced abscesses (8). In normal dogs, blood kinetic studies showed a two component exponential disappearance pattern of the radioactivity, the late half-life being from 4 to 20 hours. Direct organ counting and external computer assisted gamma camera counting showed an immediate accumulation in the lungs followed by a progressive decrease. There is a marked uptake into the liver and spleen. In bearing abscesses dogs, there is an obvious increase in local radioactivity, in spite of a decreased local blood supply, allowing scintigraphic demonstration of such foci in a limb. However, the abscess model is far from perfect and further studies are required before there is a routine use in man for the detection of abscesses.
采用“冷”焦磷酸盐和高锝[99mTc]酸盐对6只正常犬和6只松节油诱导脓肿犬进行了一种新的白细胞标记方法评估(8)。在正常犬中，血液动力学研究显示放射性呈双指数消失模式，后半衰期为4至20小时。直接器官计数和外部计算机辅助γ相机计数显示，放射性首先在肺部立即积聚，随后逐渐减少。肝脏和脾脏有明显摄取。在患脓肿犬中，尽管局部血液供应减少，但局部放射性明显增加，从而可以通过闪烁显像显示肢体中的此类病灶。然而，脓肿模型远非完美，在用于人体脓肿检测的常规应用之前，还需要进一步研究。
