血浆中芬多沙的快速荧光分析方法及口服给药后的相关数据
Rapid fluorimetric procedure for the analysis of fendosal in plasma and data following oral dosing.
作者信息
Hill H M, Chamberlain J, Hajdu P, Damm D
出版信息
Biopharm Drug Dispos. 1980 Jan-Mar;1(3):97-102. doi: 10.1002/bdd.2510010302.
A simple, rapid, and sensitive procedure is described for the determination of Fendosal in plasma. After extraction of Fendosal from buffered plasma, the drug is determined by measurement of the fluorescence induced by irradiation with short-wave ultra-violet (UV) light. The complete procedure can be completed in less than 2 h; one technician can perform up to 50 assays in one working day. The limit of detection corresponds to 0.1 microgram ml-1 plasma. Drug concentration and induced fluorescence were linearly related over the concentration range 0--8 micrograms ml-1.
本文描述了一种用于测定血浆中芬多沙尔的简单、快速且灵敏的方法。从缓冲血浆中提取芬多沙尔后，通过测量短波紫外线（UV）照射诱导的荧光来测定该药物。整个过程可在不到2小时内完成；一名技术人员在一个工作日内可进行多达50次测定。检测限相当于0.1微克/毫升血浆。在0-8微克/毫升的浓度范围内，药物浓度与诱导荧光呈线性关系。
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