先天性梅毒血清学诊断的价值。9例报告。
Value of serological diagnosis in congenital syphilis. Report of nine cases.
作者信息
Borobio M V, Nogales M C, Palomares J C
出版信息
Br J Vener Dis. 1980 Dec;56(6):377-80. doi: 10.1136/sti.56.6.377.
The diagnosis of congenital syphilis is difficult since it depends mainly on the results of serological tests. The results of five serological tests (three specific and two non-specific) in nine neonates with congenital syphilis are compared with those obtained in three with passively acquired antibodies. It appeared that the serological diagnosis of congenital syphilis must be based on the finding of specific neonatal antibodies in cord serum, which give positive results to the fluorescent treponemal antibody absorption test for immunoglobulin M, together with high titres of total IgM and negative results to latex tests. The non-specific tests are useful for confirming the efficacy of treatment. The mean number of cases of congenital syphilis in Seville is 0.81/1000 live births.
先天性梅毒的诊断较为困难，因为其主要依赖血清学检测结果。将9例先天性梅毒新生儿的5项血清学检测结果（3项特异性检测和2项非特异性检测）与3例被动获得抗体者的检测结果进行了比较。结果表明，先天性梅毒的血清学诊断必须基于脐血中特异性新生儿抗体的检测结果，这些抗体在免疫球蛋白M荧光密螺旋体抗体吸收试验中呈阳性，同时总IgM滴度较高且乳胶试验结果为阴性。非特异性检测有助于确认治疗效果。塞维利亚先天性梅毒的平均病例数为0.81/1000活产。
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