Ewing C I, Roberts C, Davidson D C, Arya O P
Arch Dis Child. 1985 Dec;60(12):1128-33. doi: 10.1136/adc.60.12.1128.
Seven cases of early congenital syphilis have been recorded in the past 10 years in the Mersey Regional Health Authority. Antenatal serology was initially negative in five mothers, who were either incubating or acquired the infection later, and treatment had probably failed in two women given erythromycin for syphilis during pregnancy. Serology should be repeated later in pregnancy in those at high risk. Social factors that define this group include women who book for antenatal care late in pregnancy, have a past history of sexually transmitted disease, and have multiple consorts. Clinical signs in the infant such as failure to thrive, hepatosplenomegaly, symmetrical rash, rhinitis, and osteochondritis should alert the clinician to the possibility of congenital syphilis. Adequate management of mother and baby requires close liaison between the genitourinary physician, microbiologist, obstetrician, and paediatrician. Penicillin remains the treatment of choice.
默西地区卫生局在过去10年里记录了7例早期先天性梅毒病例。5名母亲的产前血清学检查最初呈阴性，她们要么处于感染潜伏期，要么是后来感染的，另外有两名在孕期接受红霉素治疗梅毒的女性，治疗可能失败了。高危人群在孕期后期应再次进行血清学检查。界定这一群体的社会因素包括在孕期晚期才进行产前检查登记的女性、有性传播疾病病史的女性以及有多个性伴侣的女性。婴儿出现的诸如发育不良、肝脾肿大、对称性皮疹、鼻炎和骨软骨炎等临床症状应提醒临床医生注意先天性梅毒的可能性。对母婴进行充分管理需要泌尿生殖科医生、微生物学家、产科医生和儿科医生之间密切联络。青霉素仍然是首选治疗药物。
