Furmanski P, Saunders D E, Brooks S C, Rich M A
Cancer. 1980 Dec 15;46(12 Suppl):2794-6. doi: 10.1002/1097-0142(19801215)46:12+<2794::aid-cncr2820461410>3.0.co;2-n.
Patients with estrogen receptor (E2R)-positive breast cancers experience a longer disease-free interval and longer survival following primary surgery than do patients with E2R-negative tumors. The presence of E2R is correlated with patient age at diagnosis and tumor grade but not with the presence of metastatic foci in axillary lymph nodes. The difference in the rates of recurrence between E2R-positive and negative tumors is greater in pre- and perimenopausal patients than in postmenopausal patients.
雌激素受体（E2R）阳性乳腺癌患者在初次手术后的无病间期和生存期比E2R阴性肿瘤患者更长。E2R的存在与诊断时的患者年龄和肿瘤分级相关，但与腋窝淋巴结转移灶的存在无关。E2R阳性和阴性肿瘤之间的复发率差异在绝经前和围绝经期患者中比绝经后患者更大。
