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Estrogen receptor status and response to chemotherapy in advanced breast cancer.

作者信息

Kiang D T, Frenning D H, Gay J, Goldman A I, Kennedy B J

出版信息

Cancer. 1980 Dec 15;46(12 Suppl):2814-7. doi: 10.1002/1097-0142(19801215)46:12+<2814::aid-cncr2820461415>3.0.co;2-d.

DOI:10.1002/1097-0142(19801215)46:12+<2814::aid-cncr2820461415>3.0.co;2-d
PMID:7448726
Abstract

Tumor estrogen receptor status in women with advanced breast cancer was correlated with clinical response to cytotoxic chemotherapy in a retrospective study. Following an extramural review of the clinical data of 40 patients, 26 responded to chemotherapy (65%). The response rate in 19 receptor-rich tumors was 89% and in 21 receptor-poor tumors, 43% (P < 0.01). The lowest response rate (14%) was observed in seven postmenopausal patients with receptor-poor tumors. Clinical characteristics of patients and variants in chemotherapy programs failed to explain the favorable response of receptor-rich tumors to cytotoxic chemotherapy.

摘要

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引用本文的文献

1
Estrogen receptor status of advanced breast cancer immediately before chemotherapy does not predict for response.
Cancer Chemother Pharmacol. 1982;9(2):124-5. doi: 10.1007/BF00265394.
2
Estrogen receptors in mammary cancer: correlation with age, menopausal status, and response to therapy.乳腺癌中的雌激素受体：与年龄、绝经状态及治疗反应的相关性
J Cancer Res Clin Oncol. 1984;107(3):221-4. doi: 10.1007/BF01032611.
3
Chemotherapy of breast cancer.乳腺癌的化疗
Med Oncol Tumor Pharmacother. 1984;1(3):169-92. doi: 10.1007/BF02934139.
4
Relation of estrogen and/or progesterone receptor content of breast cancer to patient outcome following adjuvant chemotherapy.
Breast Cancer Res Treat. 1983;3(4):355-64. doi: 10.1007/BF01807588.
5
Relationship of estrogen and progesterone receptors to prognosis in breast cancer.雌激素和孕激素受体与乳腺癌预后的关系
Ann Surg. 1988 Jan;207(1):75-9. doi: 10.1097/00000658-198801000-00015.