Johansson R, Vanharanta R, Söderholm J
J Cancer Res Clin Oncol. 1984;107(3):221-4. doi: 10.1007/BF01032611.
The concentration of estrogen receptor protein (ER) in 113 primary or metastatic breast cancers was studied. ER was found to be correlated with the age of the patient. The ER values were generally lower in premenopausal patients (5.6 fmol/mg cytosol protein) than in postmenopausal patients (32.8 fmol/mg cytosol protein). The ER values of perimenopausal patients (0-5 years since the last menstrual period) were heterogeneous but generally closer to those of the premenopausal patients. Use of the ER determination for allocation of the patients either to hormonal (tamoxifen or nandrolonedecanoate) or to cytostatic (adriamycin-cyclophosphamide or Cooper's regimen) therapy was shown to result in highly satisfactory clinical response rates (including complete and partial remissions and stabilized disease) of 68% and 67%, respectively. The practical limit of ER concentration for selection is between 3 and 10 fmol/mg cytosol protein in breast cancer.
对113例原发性或转移性乳腺癌中雌激素受体蛋白（ER）的浓度进行了研究。发现ER与患者年龄相关。绝经前患者的ER值（5.6 fmol/mg胞浆蛋白）通常低于绝经后患者（32.8 fmol/mg胞浆蛋白）。围绝经期患者（末次月经后0 - 5年）的ER值存在异质性，但总体上更接近绝经前患者。结果表明，使用ER测定法将患者分配至激素治疗（他莫昔芬或癸酸诺龙）或细胞抑制治疗（阿霉素 - 环磷酰胺或库珀方案），临床缓解率（包括完全缓解、部分缓解和病情稳定）分别高达68%和67%，令人非常满意。乳腺癌选择时ER浓度的实际界限为3至10 fmol/mg胞浆蛋白。
