Lippman M E, Allegra J C
Cancer. 1980 Dec 15;46(12 Suppl):2829-34. doi: 10.1002/1097-0142(19801215)46:12+<2829::aid-cncr2820461419>3.0.co;2-m.
The usefulness of estrogen receptor (ER) analyses was assessed in a variety of clinical situations. The predictive accuracy of the test is substantially increased by quantification. ER analyses accurately predict objective responses to endocrine therapy independently of other clinical prognostic criteria. In addition, ER positivity is associated with a decreased response rate to cytotoxic chemotherapy in patients with metastatic breast cancer. Finally, the presence of ER is positively associated with a prolonged disease-free interval independent of menopausal status, tumor size, and axillary lymph node involvement.
在多种临床情况下评估了雌激素受体（ER）分析的实用性。通过定量可大幅提高该检测的预测准确性。ER分析可独立于其他临床预后标准准确预测内分泌治疗的客观反应。此外，ER阳性与转移性乳腺癌患者对细胞毒性化疗的反应率降低相关。最后，ER的存在与无病生存期延长呈正相关，且独立于绝经状态、肿瘤大小和腋窝淋巴结受累情况。
