去窦主动脉神经大鼠的假性高血压

Pseudohypertension in sinoaortic-denervated rats.

Norman R A, Coleman T G, Dent A C

Clin Sci (Lond). 1980 Dec;59 Suppl 6:303s-306s. doi: 10.1042/cs059303s.

Abstract

Mean arterial pressure was determined continuously over a 24-h period by computerized data collection in eight control and nine sinoaortic-denervated rats housed in standard-sized metabolic cages. In addition, direct and indirect pressure measurements were made while the rats were resting in a Lucite restrainer. 2. Pressure measurements made during restraint indicated that the baroreceptor-denervated rats were hypertensive: mean aortic pressure averaged 145 +/- 3.4 mmHg (mean +/- SEM) in denervated rats vs 119 +/- 2.8 mmHg in control rats (P < 0.001), and tail-cuff pressure averaged 156 +/- 5.4 mmHg compared with 121 +/- 2.7 mmHg in the control group (P < 0.001). 3. In contrast, continuous pressure monitoring showed the sinoaortic-denervated rats were normotensive (mean arterial pressure averaged 119 +/- 4.7 mmHg vs 119 +/- 3.1 mmHg in control rats). 4. Apparently arterial pressure is elevated during restraint in sinoaortic-denervated rats and pressure measurements made under these conditions give a false indication of hypertension.

摘要

通过计算机化数据收集，在标准大小的代谢笼中对8只对照大鼠和9只去窦主动脉神经大鼠连续24小时测定平均动脉压。此外，当大鼠在有机玻璃约束器中休息时，进行直接和间接压力测量。2. 在约束期间进行的压力测量表明，去压力感受器神经大鼠患有高血压：去神经大鼠的平均主动脉压平均为145±3.4 mmHg（平均值±标准误），而对照大鼠为119±2.8 mmHg（P<0.001），尾袖带压力平均为156±5.4 mmHg，而对照组为121±2.7 mmHg（P<0.001）。3. 相比之下，连续压力监测显示，去窦主动脉神经大鼠血压正常（平均动脉压平均为119±4.7 mmHg，对照大鼠为119±3.1 mmHg）。4. 显然，在约束期间，去窦主动脉神经大鼠的动脉压升高，在这些条件下进行的压力测量给出了高血压的错误指示。