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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Larkin H, Gallery E D, Hunyor S N, Gyory A Z, Boyce E S

Clin Sci (Lond). 1980 Dec;59 Suppl 6:357s-360s. doi: 10.1042/cs059357s.

Haemodynamic and left ventricular variables were determined by M-mode echocardiography in 21 normotensive and 36 hypertensive patients during the last trimester of pregnancy. 2. Blood pressure of hypertensive patients was lowered by bed rest only, or by oxprenolol or methyldopa, but remained elevated. 3. Cardiac output was raised in the last trimester of pregnancy in both normotensive and hypertensive patients. 4. Left ventricular mass was increased in normal pregnancy, but displayed an exaggerated increase in hypertensive patients. 5. Total peripheral resistance was inappropriately elevated in hypertensive pregnancy, except in the oxprenolol-treated group. 6. There ws no reduction in heart rate or cardiac output in the group treated with beta-adrenoreceptor blocking agents. These factors, in combination with normal peripheral resistance, may contribute to the improvement in foetal outcome described in maternal hypertension of pregnancy treated with oxprenolol.

在妊娠晚期，通过M型超声心动图测定了21名血压正常和36名高血压患者的血流动力学及左心室变量。2. 高血压患者的血压仅通过卧床休息，或通过氧烯洛尔或甲基多巴降低，但仍处于升高状态。3. 在妊娠晚期，血压正常和高血压患者的心输出量均升高。4. 正常妊娠时左心室质量增加，但高血压患者增加更为明显。5. 除氧烯洛尔治疗组外，高血压妊娠时总外周阻力不适当升高。6. 使用β-肾上腺素能受体阻滞剂治疗的组心率和心输出量没有降低。这些因素，再加上正常的外周阻力，可能有助于解释用氧烯洛尔治疗妊娠高血压时胎儿结局的改善情况。

Larkin H, Gallery E D, Hunyor S N, Gyory A Z, Boyce E S

Clin Sci (Lond). 1980 Dec;59 Suppl 6:357s-360s. doi: 10.1042/cs059357s.

Haemodynamic and left ventricular variables were determined by M-mode echocardiography in 21 normotensive and 36 hypertensive patients during the last trimester of pregnancy. 2. Blood pressure of hypertensive patients was lowered by bed rest only, or by oxprenolol or methyldopa, but remained elevated. 3. Cardiac output was raised in the last trimester of pregnancy in both normotensive and hypertensive patients. 4. Left ventricular mass was increased in normal pregnancy, but displayed an exaggerated increase in hypertensive patients. 5. Total peripheral resistance was inappropriately elevated in hypertensive pregnancy, except in the oxprenolol-treated group. 6. There ws no reduction in heart rate or cardiac output in the group treated with beta-adrenoreceptor blocking agents. These factors, in combination with normal peripheral resistance, may contribute to the improvement in foetal outcome described in maternal hypertension of pregnancy treated with oxprenolol.

在妊娠晚期，通过M型超声心动图测定了21名血压正常和36名高血压患者的血流动力学及左心室变量。2. 高血压患者的血压仅通过卧床休息，或通过氧烯洛尔或甲基多巴降低，但仍处于升高状态。3. 在妊娠晚期，血压正常和高血压患者的心输出量均升高。4. 正常妊娠时左心室质量增加，但高血压患者增加更为明显。5. 除氧烯洛尔治疗组外，高血压妊娠时总外周阻力不适当升高。6. 使用β-肾上腺素能受体阻滞剂治疗的组心率和心输出量没有降低。这些因素，再加上正常的外周阻力，可能有助于解释用氧烯洛尔治疗妊娠高血压时胎儿结局的改善情况。