5-溴脱氧尿苷对中国仓鼠卵巢细胞染色体畸变、姐妹染色单体交换及特定位点突变的诱导作用
Induction of chromosomes aberrations, sister chromatid exchanges, and specific locus mutations in Chinese hamster ovary cells by 5-bromodeoxyuridine.
作者信息
San Sebastian J R, O'Neill J P, Hsie A W
出版信息
Cytogenet Cell Genet. 1980;28(1-2):47-54. doi: 10.1159/000131511.
PMID:7449435
Abstract
The induction of cytotoxicity, growth inhibition, specific locus mutations, and cytological alterations such as micronuclei, chromosome/chromatid aberrations, and sister chromatid exchanged by 5-bromodeoxyuridine (BudR) in Chinese hamster ovary cells was determined. BudR shows concentration-dependent increases in cytological alterations over the range of 5-500 muM, but it is mutagenic only at concentrations greater than 50 muM.
摘要
测定了5-溴脱氧尿苷（BudR）对中国仓鼠卵巢细胞的细胞毒性、生长抑制、特定基因座突变以及细胞形态学改变（如微核、染色体/染色单体畸变和姐妹染色单体交换）的诱导作用。在5-500μM范围内，BudR诱导的细胞形态学改变呈浓度依赖性增加，但只有在浓度大于50μM时才具有致突变性。
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