Klett M, Schönberg D
Dtsch Med Wochenschr. 1981 Jan 2;106(1):6-12. doi: 10.1055/s-2008-1070246.
Screening for neonatal hypothyroidism was introduced in 1979 in nearly all West German provinces on a regional basis as an additional preventive investigation. In February 1980 provincial control was replaced by uniform financing of screening for the whole country by public sick funds. Eleven out of 14 regionally organised screening laboratories took part in an enquiry into the incidence, clinical symptoms and causes of inborn hypothyroidism. Among 427 430 newborn infants tested 137 children with inborn hypothyroidism were detected in 1979/80. The incidence of 1:3100 corresponds to European figures. On average treatment could be instigated by the 12th day of life. Clinical symptoms of hypothyroid newborns differed in part markedly from classical signs of hypothyroidism. About 30% of the mothers had goitre. The cost-benefit relationship of newborn hypothyroidism screening is 1:10.
1979年，几乎所有西德省份都开始在区域范围内开展新生儿甲状腺功能减退症筛查，作为一项额外的预防性检查。1980年2月，省级控制被公共疾病基金对全国筛查的统一资助所取代。14个区域组织的筛查实验室中有11个参与了一项关于先天性甲状腺功能减退症的发病率、临床症状和病因的调查。在1979/80年接受检测的427430名新生儿中，发现了137名患有先天性甲状腺功能减退症的儿童。1:3100的发病率与欧洲数据相符。平均而言，在出生后第12天即可开始治疗。甲状腺功能减退新生儿的临床症状部分与经典的甲状腺功能减退体征明显不同。约30%的母亲患有甲状腺肿。新生儿甲状腺功能减退症筛查的成本效益比为1:10。
