[Mechanism of silybin action, III. Resorption of the flavonolignane derivative silybin into rat liver cells (author's transl)].
作者信息
Sonnenbichler J, Mattersberger J, Hanser G
出版信息
Hoppe Seylers Z Physiol Chem. 1980 Nov;361(11):1751-6.
PMID:7450686
Abstract
After tritium labelling of silybin the time-dependent uptake of the flavonolignane derivative into rat liver was measured. Within the liver cells the distribution of silybin (and -metabolites) in cytosol, nuclear constituents and membrane material was determined and the accumulation of the flavonolignane derivative in cytosol and nuclear membranes confirmed by autoradiography. Within the nuclei a preferential binding on chromosomal proteins was found.
摘要
相似文献
1
[Mechanism of silybin action, III. Resorption of the flavonolignane derivative silybin into rat liver cells (author's transl)].
Hoppe Seylers Z Physiol Chem. 1980 Nov;361(11):1751-6.
2
[Mechanism of silybin action, IV. Structure-action relationship (author's transl)].水飞蓟宾作用机制，IV. 构效关系（作者译）
Hoppe Seylers Z Physiol Chem. 1980 Nov;361(11):1757-61.
3
4
[Influence of Silybin-dihemisuccinate on fatty acid synthesis in rat liver (author's transl)].水飞蓟宾二半琥珀酸酯对大鼠肝脏脂肪酸合成的影响（作者译）
Arzneimittelforschung. 1979;29(3):524-6.
5
Specific binding of a flavonolignane derivative to an estradiol receptor.一种黄酮木脂素衍生物与雌二醇受体的特异性结合。
Prog Clin Biol Res. 1988;280:369-74.
6
[The effect of silybin dihemisuccinate on cholesterol biosynthesis in rat liver homogenates (author's transl)].二琥珀酸半酯水飞蓟宾对大鼠肝脏匀浆中胆固醇生物合成的影响（作者译）
Arzneimittelforschung. 1977;27(9):1691-4.
7
Mechanism of the stimulation of RNA synthesis in rat liver nuclei by silybin.水飞蓟宾对大鼠肝细胞核RNA合成的刺激机制
Hoppe Seylers Z Physiol Chem. 1977 Feb;358(2):141-7. doi: 10.1515/bchm2.1977.358.1.141.
8
[Elimination of drugs in cholecystectomized patients. Studies with silymarin in patients with extrahepatic complications].[胆囊切除患者的药物消除。水飞蓟宾对肝外并发症患者的研究]
Methods Find Exp Clin Pharmacol. 1981;3 Suppl 1:103-106S.
9
Silybin inhibition of amatoxin uptake in the perfused rat liver.水飞蓟宾对灌注大鼠肝脏中鹅膏毒素摄取的抑制作用。
Arzneimittelforschung. 1980;30(3):452-4.
10
[Bioavailability of silymarin, I: Volumes of distribution of silybin, silydianin, and silychristin from in-vitro data (author's transl)].
Arch Pharm (Weinheim). 1981 Jun;314(6):515-7. doi: 10.1002/ardp.19813140608.
引用本文的文献
1
Comparative bioavailability of Silipide, a new flavanolignan complex, in rats.
Eur J Drug Metab Pharmacokinet. 1992 Jan-Mar;17(1):39-44. doi: 10.1007/BF03189986.
Zotero 插件