水飞蓟宾对灌注大鼠肝脏中鹅膏毒素摄取的抑制作用。
Silybin inhibition of amatoxin uptake in the perfused rat liver.
作者信息
Faulstich H, Jahn W, Wieland T
出版信息
Arzneimittelforschung. 1980;30(3):452-4.
PMID:7387753
Abstract
Silybin dihemisuccinate, in a concentration of 0.4 mg/ml, almost completely inhibited the uptake of an amatoxin by the perfused rat liver. Similary, silybin should also interrupt absorption of toxins due to enterohepatic circulation, e.g. in dog and man. This effect may become important in the therapy of human Amanita poisoning.
摘要
半琥珀酸水飞蓟宾浓度为0.4毫克/毫升时，几乎能完全抑制灌注大鼠肝脏对鹅膏毒素的摄取。同样，水飞蓟宾也应能阻断因肠肝循环导致的毒素吸收，如在犬类和人类中。这种作用在人类 Amanita 中毒治疗中可能具有重要意义。
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