人生长激素对垂体功能减退症患者血液中多胺的影响。

Effects of human growth hormone on blood polyamines in hypopituitarism.

作者信息

Bernasconi S, Casti A, Orlandini G, Reali N, Virdis R, Giovannelli G

出版信息

Helv Paediatr Acta. 1980 May;35(2):141-8.

Abstract

Blood levels of polyamines were evaluated in hypopituitary patients after i.m. injection of human growth hormone (hGH). After hGH administration polyamine concentration increased significantly in the first 60 minutes. The concentration of spermidine and spermine increases more in patients previously untreated or treated intermittently with hGH than in patients under continuous treatment. The results suggest that in human as well as in experimental models, polyamines could be involved in the growth process and that hGH probably stimulates polyamine synthesis.

摘要

对垂体功能减退患者进行肌肉注射人生长激素（hGH）后，评估其血液中的多胺水平。注射hGH后，多胺浓度在最初60分钟内显著增加。与持续接受治疗的患者相比，先前未接受治疗或间歇性接受hGH治疗的患者中，亚精胺和精胺的浓度升高幅度更大。结果表明，在人类以及实验模型中，多胺可能参与生长过程，并且hGH可能刺激多胺合成。