Casti A, Bernasconi S, Orlandini G, Cantarelli A, Reali N, Corti A
Ateneo Parmense Acta Biomed. 1979;50(1):59-67.
Blood polyamines were evaluated in normal children of various ages (from infancy to adolescence). Polyamines show a distinctive pattern: maximal values were observed during infancy; they decrease during childhood and again increase at puberty. After i.m. injection of Human Growth Hormone (HGH), polyamine concentrations increase significantly in the first 60 minutes. Polyamines increase more in patients previously untreated or treated intermittently with HGH than in patients under continuous treatment. The results suggest that in humans as well as in animals, polyamines could be involved in the growth processes and that the effect of HGH probably consists in a stimulation of polyamine synthesis.
对不同年龄段（从婴儿期到青春期）的正常儿童的血液多胺进行了评估。多胺呈现出一种独特的模式：在婴儿期观察到最大值；在儿童期下降，并在青春期再次升高。肌肉注射人生长激素（HGH）后，多胺浓度在最初60分钟内显著增加。与持续接受HGH治疗的患者相比，以前未接受治疗或间歇性接受HGH治疗的患者中多胺增加得更多。结果表明，在人类和动物中，多胺可能参与生长过程，并且HGH的作用可能在于刺激多胺合成。
