将在动物身上获得的药理结果外推至人体。
Extrapolation to man of pharmacological results obtained on animals.
作者信息
Dreyer A C
出版信息
J S Afr Vet Assoc. 1978 Sep;49(3):259-60.
PMID:745210
Abstract
Drug development relies on the assumption of a high degree of correlation between the effects of drugs in animals and man. While a good correlation exists as far as the pharmacodynamic action of the drug is concerned it is usually the unpredictable pharmacokinetic properties of the drug responsible for obscuring proper correlations.
摘要
药物研发基于这样一种假设
药物在动物和人体中的作用具有高度相关性。就药物的药效学作用而言，确实存在良好的相关性，但通常是药物不可预测的药代动力学特性导致难以建立恰当的相关性。
Zotero 插件