El Hani A, Dalle M, Delost P
J Endocrinol. 1980 Dec;87(3):455-61. doi: 10.1677/joe.0.0870455.
Sexual dimorphism in adrenal activity appeared during the pubertal period of the guinea-pig with plasma levels and binding of cortisol lower in male guinea-pigs compared with female, and metabolic clearance rate (MCR) of cortisol higher in male than in female animals. Gonadectomy of female guinea-pigs did not change the values of the parameters regulating adrenal activity. Castration of male guinea-pigs caused a rise in plasma cortisol levels by increasing the binding capacity of transcortin for cortisol and by decreasing cortisol MCR. Treatment of females with testosterone from day 24 produced a drop on day 50 in plasma cortisol levels following a decreased binding capacity of transcortin for cortisol and at the same time as cortisol MCR increased. Furthermore, the adrenal response to stress was higher in castrated than in control males and lower in testosterone-treated females compared with control females. Testosterone appeared to be the hormone responsible for sexual dimorphism in adrenal activity in the pubertal guinea-pig.
豚鼠青春期时肾上腺活动出现性别二态性，雄性豚鼠的血浆皮质醇水平及结合能力低于雌性，且雄性动物皮质醇的代谢清除率（MCR）高于雌性。对雌性豚鼠进行性腺切除并未改变调节肾上腺活动的参数值。对雄性豚鼠进行去势，通过增加皮质素结合皮质醇的能力以及降低皮质醇MCR，导致血浆皮质醇水平升高。从第24天开始用睾酮处理雌性豚鼠，在第50天时，由于皮质素结合皮质醇的能力下降，同时皮质醇MCR增加，血浆皮质醇水平下降。此外，去势雄性豚鼠对压力的肾上腺反应高于对照雄性，而睾酮处理的雌性豚鼠对压力的肾上腺反应低于对照雌性。睾酮似乎是导致青春期豚鼠肾上腺活动出现性别二态性的激素。
