Manin M, Delost P
Steroids. 1984 Jan;43(1):101-10. doi: 10.1016/0039-128x(84)90062-x.
The effect of estradiol on adrenal secretion rate of cortisol in response to a stress induced by anesthesia, was examined by comparing the metabolic clearance rate and the production rate of cortisol between males and females and after estradiol administration in castrated animals. Metabolic clearance rates of cortisol (MCR) were significantly higher (+30%) in males than in females. Castration lowered the MCR of cortisol in males and had no significant effect in females. After estradiol administration, a fall in the MCR of cortisol concomitant with a rise in blood cortisol level was observed especially in males in which the effect of treatment was more marked than in females and highly significant. The production rate of cortisol was identical in males and females and was slightly increased in estradiol-treated males and females. The data indicate that estradiol had an inhibitory effect on metabolic clearance of cortisol, which caused an important rise of blood cortisol levels in response to stress and which prevented an increase in the adrenal response to the stress. Since the pituitary adrenal cortex can respond in a normal way to stress, the low value of MCR of cortisol could be the limiting factor in the adrenal secretion rate of cortisol in estrogen-treated guinea-pigs.
通过比较雄性和雌性以及阉割动物给予雌二醇后皮质醇的代谢清除率和生成率，研究了雌二醇对麻醉诱导应激反应中肾上腺皮质醇分泌率的影响。雄性皮质醇的代谢清除率（MCR）显著高于雌性（高30%）。阉割降低了雄性皮质醇的MCR，对雌性无显著影响。给予雌二醇后，观察到皮质醇MCR下降，同时血皮质醇水平升高，尤其是雄性，治疗效果在雄性中比在雌性中更明显且具有高度显著性。雄性和雌性皮质醇的生成率相同，雌二醇处理的雄性和雌性皮质醇生成率略有增加。数据表明，雌二醇对皮质醇的代谢清除具有抑制作用，这导致应激反应中血皮质醇水平显著升高，并阻止肾上腺对应激反应的增加。由于垂体肾上腺皮质能够以正常方式对应激作出反应，皮质醇MCR的低值可能是雌激素处理的豚鼠肾上腺皮质醇分泌率的限制因素。
