Carter J, Reynoldson J A, Thorburn G D
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;83(2):401-6. doi: 10.1016/0742-8413(86)90143-x.
Vasodilating prostaglandins were injected, in bolus doses, into the lower abdominal aorta or left circumflex coronary artery (LCCA) of conscious sheep. Local blood flow, mean arterial pressure (MAP), heart rate (HR) and ECG were monitored continuously. 6-Keto PGF1 alpha had no effect on either vascular bed in doses up to 100 micrograms. PGE2 was more potent than PGI2 in dilating hindlimb vasculature and PGE2 induced a more persistent hyperaemia whereas PGD2 elicited a biphasic response (constriction-dilation). PGE1, PGE2, PGD2 and PGI2 all produced dose-dependent vasodilation, the order of potency being PGD2 greater than PGI2 greater than PGE1 greater than or equal to PGE2. The effect of PGI2 was more transient and PGE1 and PGD2 caused small but consistent decreases in MAP and HR, respectively.
将血管舒张性前列腺素以大剂量推注的方式注入清醒绵羊的腹主动脉下段或左旋冠状动脉（LCCA）。持续监测局部血流、平均动脉压（MAP）、心率（HR）和心电图。剂量高达100微克时，6-酮前列环素F1α对任何一个血管床均无影响。在扩张后肢血管方面，前列腺素E2（PGE2）比前列环素（PGI2）更有效，且PGE2诱导的充血更持久，而前列腺素D2（PGD2）引发双相反应（收缩-舒张）。前列腺素E1（PGE1）、PGE2、PGD2和PGI2均产生剂量依赖性血管舒张，效力顺序为PGD2＞PGI2＞PGE1≥PGE2。PGI2的作用更短暂，PGE1和PGD2分别导致MAP和HR出现微小但持续的下降。
