Young S W, Muller H H, Marincek B
Radiology. 1981 Jan;138(1):97-105. doi: 10.1148/radiology.138.1.7455104.
Rabbits with V2 carcinoma thigh implants received intravenous injections of solutions of polyvinylpyrrolidone (PVP) and metallic salts. This resulted in dense contrast enhancement of the carcinomas in some of the studies, as determined both by computed tomography (CT) and conventional radiography. The contrast enhancement lasted for several weeks, greatly facilitating tumor detection. The magnitude and duration of this contrast enhancement would be expected to improve CT detection of small lesions and to be useful in evaluating the efficacy of therapy.
患有大腿V2癌植入物的兔子接受了聚乙烯吡咯烷酮（PVP）和金属盐溶液的静脉注射。在一些研究中，这导致了癌灶的高密度对比增强，这是通过计算机断层扫描（CT）和传统放射摄影确定的。这种对比增强持续了数周，极大地促进了肿瘤的检测。这种对比增强的程度和持续时间有望改善CT对小病灶的检测，并有助于评估治疗效果。
