Young S W, Rumbaugh C L
Invest Radiol. 1978 Jul-Aug;13(4):334-6. doi: 10.1097/00004424-197807000-00011.
After a bolus of intravenous Renografin, the delivery and washout of contrast in malignant V2 carcinoma, normal muscle, and blood using CT scanning was evaluated over a two-hour period. Diagnostically useful differences in enhancement between V2 carcinoma and muscle predictably lasted one hour, but in selected rabbits lasted longer. Delivery and washout was greater in tumor than in normal muscle, and it was these differences which accounted for the diagnostically useful differences in enhancement. After two hours, attenuation in V2 and normal muscle remained elevated, while blood returned to nearly control levels, suggesting a large amount of contrast distributed throughout the extravascular space and probably in equilibrium with excretion.
静脉注射一次泛影葡胺后，在两小时内使用CT扫描评估了恶性V2癌、正常肌肉和血液中造影剂的输送和清除情况。V2癌和肌肉之间增强的诊断有用差异可预测地持续了一小时，但在部分兔子中持续时间更长。肿瘤中的造影剂输送和清除比正常肌肉中更大，正是这些差异导致了增强方面的诊断有用差异。两小时后，V2和正常肌肉中的衰减仍保持升高，而血液则恢复到接近对照水平，这表明大量造影剂分布在整个血管外空间，可能与排泄处于平衡状态。
