Gregg R E, Zech L A, Schaefer E J, Brewer H B
Science. 1981 Feb 6;211(4482):584-6. doi: 10.1126/science.7455696.
The apolipoprotein E isolated from plasma of individuals with type III hyperlipoproteinemia (HLP) shows an abnormal pattern when it is examined by isoelectric focusing. Compared to apolipoprotein E from normal subjects, apolipoprotein E isolated from subjects with type III HLP had a decreased fractional catabolic rate in vivo in both type III HLP patients and normal individuals. The delayed catabolism of apolipoprotein E in type III HLP patients may be responsible for the lipid and lipoprotein abnormalities characteristic of these patients.
从Ⅲ型高脂蛋白血症（HLP）患者血浆中分离出的载脂蛋白E，经等电聚焦检测时显示出异常模式。与正常受试者的载脂蛋白E相比，从Ⅲ型HLP患者中分离出的载脂蛋白E在Ⅲ型HLP患者和正常个体体内的分数分解代谢率均降低。Ⅲ型HLP患者载脂蛋白E分解代谢延迟可能是这些患者脂质和脂蛋白异常的原因。
