Gudim V I, Sigalla P, Ivanova V S, Oldag K
Vopr Med Khim. 1980 Nov-Dec;26(6):742-6.
Blood serum from children and young patients with chronic kidney insufficiency at the terminal step as well as from healthy donors was fractionated using ultrafilters "Amicon" XM-50 and Sephadex G-25. Three fractions were obtained: F1--molecular mass 50,000-5,000, F3--3,000-800 (fraction of middle mass molecules, MM) and F5 < 200. Amount of protein in the MM fraction exceeded 7-10-fold the protein content in the same fraction of donor blood serum. Hemodialysis decreased dissimilarly the MM concentration in blood serum of various patients, but the content of this fraction was decreased approximately by 37% after the treatment; the constant value was obtained as a result of calculation per an hour of hemodialysis and per kg of body mass. These data suggest that elimination of the MM fraction from blood serum of patients with chronic kidney insufficiency depends on the period of the short-term hemodialysis.
对处于终末期的慢性肾功能不全儿童及年轻患者以及健康供体的血清，使用“密理博”XM - 50超滤器和葡聚糖G - 25进行分级分离。得到三个级分：F1——分子量50,000 - 5,000，F3——3,000 - 800（中等分子量分子级分，MM）和F5＜200。MM级分中的蛋白量比供体血清相同级分中的蛋白含量高出7 - 10倍。血液透析对不同患者血清中MM浓度的降低程度不同，但该级分的含量在治疗后大约降低了37%；通过每小时血液透析及每千克体重计算得出恒定值。这些数据表明，慢性肾功能不全患者血清中MM级分的清除取决于短期血液透析的时长。
