Grafnetterová J, Vodrázka Z, Jandová D, Schück O, Tomásek R, Lachmanová J
Clin Nephrol. 1976 Oct;6(4):448-50.
The binding (r) of chloramphenicol to serum proteins is significantly lower in patients with chronic renal failure than in normal subjects. Before hemodialysis, the mean r value in patients with chronic renal insufficiency was 0.165 mg/g (+/-0.003) versus 0.188 mg/g (+/-0.004) in healthy individuals. Hemodialysis produced a significant rise in r (to 0.182 mg/g, +/-0.004). Decrease in the serum concentration of albumin in patients with chronic renal insufficiency does not seem to be the sole factor responsible for decreased r.
慢性肾衰竭患者中氯霉素与血清蛋白的结合率（r）显著低于正常受试者。血液透析前，慢性肾功能不全患者的平均r值为0.165mg/g（±0.003），而健康个体为0.188mg/g（±0.004）。血液透析使r值显著升高（至0.182mg/g，±0.004）。慢性肾功能不全患者血清白蛋白浓度降低似乎并非导致r值降低的唯一因素。
