Samuels S, Fish I, Freedman L S
Neurochem Res. 1978 Oct;3(5):619-31. doi: 10.1007/BF00963763.
Two inhibitors of the gamma-glutamyl cycle, methionine sulfoximine (MSO) and 2-imidazolidone-4-carboxylic acid (ICA) were administered to C57LB/6J mice. Both agents resulted in a reduced rate of transport of tyrosine from blood to brain and a decreased rate of incorporation of tyrosine from plasma into brain protein. MSO administration also diminished to concentrations of brain tyrosine, dopamine, and norepinephrine. MSO decreased the transport rate of valine by brain as well as the rate of its incorporation into protein when expressed in relation to the plasma specific activity. The results demonstrate a significant role for the gamma-glutamyl cycle in the transport of large neutral amino acids from blood to brain.
给C57LB/6J小鼠注射了γ-谷氨酰循环的两种抑制剂，即蛋氨酸亚砜亚胺（MSO）和2-咪唑烷酮-4-羧酸（ICA）。两种药物均导致酪氨酸从血液到脑的转运速率降低，以及血浆中酪氨酸掺入脑蛋白的速率下降。注射MSO还使脑内酪氨酸、多巴胺和去甲肾上腺素的浓度降低。当以血浆比活性表示时，MSO降低了脑对缬氨酸的转运速率及其掺入蛋白质的速率。结果表明γ-谷氨酰循环在大中性氨基酸从血液到脑的转运中起重要作用。
