Randt C T, Samuels S, Fish I
Pharmacol Biochem Behav. 1976 Jun;4(6):689-94. doi: 10.1016/0091-3057(76)90221-5.
In vivo inhibition of uptake 14C-L-valine by brain following subcutaneous administration of either of two gamma-glutamyl cycle enzyme inhibitors, 2-imidazolidone-4-carboxylic acid (ICA), or, L-methionine-S-sulfoximine (MSO) is documented in C57BL/6J mice. Dose related decrease in exploratory activity, impairment of memory for foot shock, and reduced operant responding for food reinforcement parallels the time course for interference with uptake of a large neutral amino acid by these two compounds previously shown to inhibit different enzymes in the gamma-glutamyl cycle subserving active amino acid transport.
在C57BL/6J小鼠中记录到，皮下注射两种γ-谷氨酰循环酶抑制剂中的任何一种，即2-咪唑啉酮-4-羧酸（ICA）或L-蛋氨酸-S-亚砜亚胺（MSO）后，脑内对14C-L-缬氨酸摄取的体内抑制作用。探索活动的剂量相关性降低、对足部电击记忆的损害以及对食物强化的操作性反应减少，与这两种化合物干扰大中性氨基酸摄取的时间进程平行，这两种化合物先前已被证明可抑制γ-谷氨酰循环中不同的酶，该循环参与活性氨基酸转运。
