Samuels S, Randt C T, Fish I, Schwartz S A
Pharmacol Biochem Behav. 1986 Jan;24(1):143-6. doi: 10.1016/0091-3057(86)90058-4.
DBA/2J mice were exposed in utero, between days 15-18 of gestation, to either of two enzyme inhibitors, previously shown to decrease blood-brain, large-neutral amino acid transport in adults: L-methionine-RS-sulfoximine and 2-imidazolidone-4-carboxylic acid. The young mice demonstrated persistently altered motor behavior relative to saline controls when 40-42 days old and evidence of differences in the entry and incorporation of 14C-valine in brain at up to 80 days of age. The findings suggest that interference with blood-brain amino acid transport in utero has long term consequences. This may be related to some human conditions such as maternal phenylketonuria.
在妊娠第15至18天期间，将DBA/2J小鼠在子宫内暴露于两种酶抑制剂中的任何一种，这两种抑制剂先前已被证明可降低成年小鼠血脑屏障对大中性氨基酸的转运：L-蛋氨酸-RS-亚砜亚胺和2-咪唑烷酮-4-羧酸。这些幼鼠在40至42日龄时相对于生理盐水对照组表现出持续改变的运动行为，并且在长达80日龄时，有证据表明其大脑中14C-缬氨酸的进入和掺入存在差异。这些发现表明，子宫内对血脑氨基酸转运的干扰具有长期影响。这可能与某些人类疾病有关，如母体苯丙酮尿症。
