Trost H, Böni A
Z Rheumatol. 1980 Sep-Oct;39(9-10):309-13.
Oral administration of anticonvulsive drugs like hydantoin can induce a syndrome similar to systemic lupus erythematosus (SLE). This syndrome is characterized by development of typical symptoms or signs of SLE following the drug administration, occurrence of a significant elevation of ANA titer (above 1:40), and clinical remission after dropping the anticonvulsive treatment. A patient is reported and the typical clinical features and laboratory (mainly serological) findings of hydantoin-induced SLE are discussed. The potentially SLE-inducing drugs are reviewed.
口服像乙内酰脲这样的抗惊厥药物可诱发一种类似于系统性红斑狼疮（SLE）的综合征。该综合征的特征为在服用药物后出现SLE的典型症状或体征，抗核抗体（ANA）滴度显著升高（高于1:40），以及在停用抗惊厥治疗后临床缓解。本文报告了一例患者，并讨论了乙内酰脲诱发的SLE的典型临床特征和实验室（主要是血清学）检查结果。对可能诱发SLE的药物进行了综述。
