Katz M S, Gregerman R I, Horvath E, Kovacs K, Ezrin C
Acta Endocrinol (Copenh). 1980 Sep;95(1):41-8. doi: 10.1530/acta.0.0950041.
The morphological features of a pituitary adenoma resected from a 39-year-old woman with hypothyroidism have been investigated. Hypothyroidism followed radioactive iodine treatment of pre-existing hyperthyroidism, presumably Graves' disease. Blood TSH was low during a euthyroid interval and was elevated above normal with the onset of hypothyroidism. The presence of a small amount of TSH was demonstrated in the tumour by radioimmunoassay. By conventional histology the tumour was a chromophobe adenoma. Some fine secretory granules stained with aldehyde thionin but were negative with PAS and contained no immunoreactive TSH. By light and electron microscopy, the tumour cells differed from thyroid deficiency cells. They were small and angular, containing numerous microtubules and small spherical secretory granules, oriented mainly along the plasma membranes. The tumour was considered to represent a thyrotroph cell adenoma, arising from protracted overstimulation secondary to chronic thyroid hormone deficiency.
对一名39岁甲状腺功能减退女性切除的垂体腺瘤的形态学特征进行了研究。该甲状腺功能减退是在先前存在的甲状腺功能亢进（推测为格雷夫斯病）接受放射性碘治疗后出现的。在甲状腺功能正常期间，血液促甲状腺激素（TSH）水平较低，而随着甲状腺功能减退的出现，其水平高于正常。通过放射免疫分析在肿瘤中检测到少量TSH。根据传统组织学，该肿瘤为嫌色性腺瘤。一些细小的分泌颗粒用醛性硫堇染色，但对过碘酸雪夫反应（PAS）呈阴性，且不含免疫反应性TSH。通过光镜和电镜观察，肿瘤细胞与甲状腺功能减退细胞不同。它们体积小且呈角形，含有大量微管和小的球形分泌颗粒，主要沿质膜排列。该肿瘤被认为代表一种促甲状腺激素细胞腺瘤，由慢性甲状腺激素缺乏继发的长期过度刺激引起。
