Ungváry G, Cseh J, Mányai S, Molnár A, Szeberényi S, Tátrai E
Acta Med Acad Sci Hung. 1980;37(1):115-20.
Inhalation of 4500 mg o-xylene by rats was found to produce adaptational and pathologic changes in the liver by the end of the 1st week, reflected in an increase in relative liver weight, shortening of the hexobarbital sleeping time, an increase in the concentration of cytochrome P-450, with a decrease in the activities of aniline hydroxylase and of aminopyrine N-demethylase. Six weeks after the start of inhalations all the changes in the liver and in the mixed function oxydase system (MFO) were of an adaptational pattern characterized by an increase in relative liver weight as well as in cytochrome P-450 and b5 concentrations, a shortening of the hexobarbital sleeping time and an increase in the activity of aniline hydroxylase and of aminopyrine N-demethylase.
研究发现，大鼠吸入4500毫克邻二甲苯后，在第1周结束时肝脏会产生适应性和病理性变化，表现为肝脏相对重量增加、己巴比妥睡眠时间缩短、细胞色素P - 450浓度升高，同时苯胺羟化酶和氨基比林N - 脱甲基酶的活性降低。吸入开始六周后，肝脏和混合功能氧化酶系统（MFO）的所有变化均呈现适应性模式，其特征为肝脏相对重量以及细胞色素P - 450和b5浓度增加、己巴比妥睡眠时间缩短、苯胺羟化酶和氨基比林N - 脱甲基酶的活性增加。
