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慢性活动性肝炎中的人类白细胞抗原

HLA antigens in chronic active hepatitis.

作者信息

Pár A, Bajtai G, Gyódi E, Ambrus M, Hernádi E, Tényi I

出版信息

Acta Med Acad Sci Hung. 1980;37(1):17-24.

PMID:7457016
Abstract

Seventy-five patients (28 HBsAg-positive and 28 HBsAg-negative) with chronic active hepatitis (CAH) were studied for HLA antigens. In the whole material, the HLA antigens were distributed as in the controls, with the only exception of the HLA-A9 antigen, the frequency of which, as compared with the controls, was moderately increased (37.4% against 22.7%). It was mainly the HBsAg-negative group which showed a significant increase in the frequency of the HLA-A9 antigen (42.9%). In the HBsAg-negative group, as compared with the HBsAg-positive group, where the frequency of HLA-A2 was 53.2%--and as compared with the controls, too--it was relatively low 29.3%. The frequency of HLA-A1 and HLA-B8 was not increased in any type of chronic active hepatitis. HLA-B8 was less frequent in the HBsAg-positive than in the HBsAg-negative group (10.6% against 21.4%).

摘要

对75例慢性活动性肝炎(CAH)患者(28例HBsAg阳性和28例HBsAg阴性)进行了HLA抗原研究。在整个研究对象中,HLA抗原的分布与对照组相同,唯一例外的是HLA - A9抗原,其频率与对照组相比有适度增加(37.4%对22.7%)。主要是HBsAg阴性组HLA - A9抗原频率显著增加(42.9%)。在HBsAg阴性组中,与HBsAg阳性组相比(HBsAg阳性组中HLA - A2频率为53.2%),并且与对照组相比,其频率相对较低,为29.3%。在任何类型的慢性活动性肝炎中,HLA - A1和HLA - B8的频率均未增加。HBsAg阳性组中HLA - B8的频率低于HBsAg阴性组(10.6%对21.4%)。

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