Tátrai E, Ungváry G
Acta Med Acad Sci Hung. 1980;37(2):211-6.
Rats subjected to inhalation of 3500 ppm o-xylene for 6 weeks were found to increase their body-weight at a lower rate than did the controls, despite an increased food and fluid intake, and to develop hepatic enlargement. Post mortem studies revealed no other abnormality. The distribution of the hepatocellular nuclei according to size was, however, modified. The proportion of large nuclei was higher in the test animals than in the controls, and the number of cells per unit area was lower, as a sign of cellular hypertrophy. Electron microscopic studies revealed a loss of glycogen, and increase of rough and smooth endoplasmic reticulum and of peroxisomes. These changes which are typical of the adaptational phase of poisoning may be connected with the induction of the mixed function oxidase system. Enzyme histochemical and ultrastructural studies also revealed a slight hepatocellular damage.
吸入3500 ppm邻二甲苯6周的大鼠，尽管食物和液体摄入量增加，但体重增加速度低于对照组，且出现肝脏肿大。尸检研究未发现其他异常。然而，肝细胞细胞核按大小的分布发生了改变。与对照组相比，试验动物中较大细胞核的比例更高，单位面积的细胞数量更低，这是细胞肥大的迹象。电子显微镜研究显示糖原减少，粗面和滑面内质网以及过氧化物酶体增加。这些典型的中毒适应期变化可能与混合功能氧化酶系统的诱导有关。酶组织化学和超微结构研究也显示有轻微的肝细胞损伤。
