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多发性骨髓瘤与胃癌。腹部有限X线照射可能产生的迟发效应。

Multiple myeloma and gastric carcinoma. Possible late effects of limited abdominal X-irradiation.

作者信息

Peters M, Mackay I R

出版信息

Acta Med Scand. 1980;208(5):411-5.

PMID:7457210
Abstract

A man, aged 34, was treated in 1954 for duodenal ulcer by antroduodenectomy followed by X-irradiation to the stomach in a dose of 2,000 rads. Over two decades, he developed several conditions attributable to the previous irradiation, including the physical appearances of premature ageing, shrinkage of the left kidney due to irradiation nephritis, immune deficiency, multiple myeloma of IgA type, and lastly, carcinoma of the stomach. The kidneys, especially the left, the bone marrow and stomach would have been in the field of X-irradiation. These effects of local X-irradiation are discussed in relation to the known effects of total body irradiation in causing decreased longevity in animals and inducing cancer in man.

摘要

一名34岁男性于1954年接受了十二指肠溃疡治疗,行胃窦十二指肠切除术,随后对胃部进行了2000拉德的X线照射。二十多年来,他出现了多种与先前照射有关的病症,包括早衰的体征、因放射性肾炎导致的左肾萎缩、免疫缺陷、IgA型多发性骨髓瘤,最后还有胃癌。肾脏,尤其是左肾、骨髓和胃都在X线照射范围内。本文结合全身照射对动物寿命缩短和人类致癌的已知影响,讨论了局部X线照射的这些效应。

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