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[仔猪静脉注射果糖和半乳糖负荷后耐受性的年龄依赖性]

[Age-dependence of fructose and galactose tolerance following intravenous loading in piglets].

作者信息

Gürtler H, Stöhr J, Brenner K V

出版信息

Arch Exp Veterinarmed. 1980;34(5):767-75.

PMID:7458564
Abstract

Fructose tolerance tests were applied to 54 piglets, aged between zero and 20 hours, two and three, five and seven, as well as 20 and 30 days. Fructose injections per kilogram of body weight were 0.5 g and 1.0 g. Galactose tolerance tests were applied to 33 piglets, aged between zero and 20 hours as well as between five and seven or 20 and 35 days. The galactose dose per kilogram of body weight was 0.5 g. Very slow or no fructose elimination at all was recordable from the circulation of animals, aged between zero and 20 hours, yet, with elimination rates being accelerated along with growing age. Piglets, aged between 20 and 30 days, eliminated fructose from the blood just as fast as glucose (th = 0.49 +/- 0.11 hr). Fructose depressed the glucose levels in the blood in animals, aged between five and seven days, but it failed to do so in animals, aged between 20 and 30 days, Galactose was found to be eliminated speedily from the circulation, that is immediately after birth, a maximum being reached at an age between five and seven days (th = 0.11 +/- 0.02 hr). Fructose space in piglets, aged between five and seven or between 20 and 30 days, was found to be significantly below that recorded from the two younger age groups. Galactose space in piglets, aged between five and seven days, was significantly below that of the other two groups.

摘要

对54头年龄在0至20小时、2至3天、5至7天以及20至30天的仔猪进行了果糖耐量试验。每千克体重的果糖注射量为0.5克和1.0克。对33头年龄在0至20小时以及5至7天或20至35天的仔猪进行了半乳糖耐量试验。每千克体重的半乳糖剂量为0.5克。在0至20小时龄的动物循环系统中,可记录到果糖消除非常缓慢或根本没有消除,但随着年龄增长,消除速率加快。20至30日龄的仔猪从血液中消除果糖的速度与葡萄糖一样快(th = 0.49 +/- 0.11小时)。果糖降低了5至7日龄动物血液中的葡萄糖水平,但在20至30日龄的动物中没有这种作用。发现半乳糖从循环系统中迅速消除,即在出生后立即开始,在5至7日龄时达到最大值(th = 0.11 +/- 0.02小时)。5至7日龄或20至30日龄仔猪的果糖空间显著低于两个较年轻年龄组的记录值。5至7日龄仔猪的半乳糖空间显著低于其他两组。

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