[DNA damage and repair induced in vivo by benzidine treatment].

DNA damage was evaluated in kidney and liver of mice treated with benzidine at the dose of 150 mg/Kg. The data presented show that the liver can be considered as the target tissue more influenced by the benzidine metabolites. The maxima of DNA fragmentation in the liver and kidney were at 4 and 2 hours respectively after treatment. Moreover the induced DNA damage in kidney and liver of mice treated was evaluated in the time depending from the rate of repair synthesis.